منابع مشابه
Terminating B cell receptor signaling
Bruton’s tyrosine kinase (BTK) mediated signaling is critical for B cell development and activation. The physiological role of BTK is evident since its functional loss results in a differentiation block of B cells beyond the pro-B cell stage causing X-linked agammaglobulinemia. Inhibitors of BTK, such as ibrutinib and acalabrutinib profoundly impair BCR signaling. They are highly effective in t...
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The role of the paxillin superfamily of adaptor proteins in B cell antigen receptor (BCR) signaling has not been studied previously. We show here that leupaxin (LPXN), a member of this family, was tyrosine-phosphorylated and recruited to the plasma membrane of human BJAB lymphoma cells upon BCR stimulation and that it interacted with Lyn (a critical Src family tyrosine kinase in BCR signaling) ...
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Rituximab (RTX), a monoclonal antibody directed against the CD20 protein, is a drug commonly used in the treatment of B-cell-derived lymphoid neoplasias and of antibody-mediated autoimmune diseases. In addition to cell- and complement-mediated B-cell depletion, RTX is thought to inhibit B-cell survival and proliferation through negative regulation of canonical signaling pathways involving Akt, ...
متن کاملB Cell Receptor Signaling in Human B Cells
B cells play an important role in the early phase of the immune response particularly in polysaccharide-encapsulated bacteria-induced responses, in which B and T cell cooperation is interfered. The mechanisms of these T cell-independent (TI) -antigen-induced B cell responses have been studied mainly in mice, but the responses and the role of BCR-mediated activation in human B cells are not know...
متن کاملPI3K Signaling in B Cell and T Cell Biology
The drug Idelalisib is the first PI3K inhibitor to be approved by the FDA for clinical use. It is therefore timely to take stock of our current understanding of the role of PI3Ks in the immune system. The phosphoinositide 3-kinases (PI3Ks) control many key functions in immune cells (1). PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3, which acts as a second messenger signaling molecu...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 1999
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.22.378